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I am using LyX for two years and prefer it - mainly beacuse it is a less distracting place to write than in a file with lots of markup visible.
It has lots of great usability features (e.g.
In version 2 they have much improved features like spell checking. It is cross platform - I can write from windows or Mac and build the doc from windows or mac and get exactly the same result. :-)
On Mac I sometimes use editors that come with the texLive distribution and on Windows the same texworks. I prefer these to LeD.
Recently other options are opening with the extensive multimarkdown support for LaTeX generation this and tools like Tex Touch are taking LaTeX up a level in usability.
Check out org mode running in Emacs with babel (get the Emacs version from Vincent Gourlay at http://vgoulet.act.ulaval.ca/en/emacs/ it has org mode already installed).
Here you use mmd mark up to get a simple writing experience and then make a PDF using LaTeX with a keystoke. Very cool.
There is even mobile org allowing you to edit & sync org files from a smart phone.
I'm on the Mac, and I use TexShop. It's got all the GUI bells and whistles, and a big open space for the code.
On the Windows machine, it's Texniccenter for me, too, but I work on LaTex very rarely there.
I'm not a heavy user, though, so these do the job for me.